阳离子钯（II）催化芳酰甲基2-炔酸酯的对映选择性环化反应，该反应由炔烃与芳基硼酸的碳钯化引发。
Cationic Pd(II)-catalyzed enantioselective cyclization of aroylmethyl 2-alkynoates initiated by carbopalladation of alkynes with arylboronic acids.
作者信息
Song Juan, Shen Qi, Xu Fan, Lu Xiyan
机构信息
Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou, China.
出版信息
Org Lett. 2007 Jul 19;9(15):2947-50. doi: 10.1021/ol0711772. Epub 2007 Jun 20.
PMID:17580892
Abstract
A cationic palladium(II)-catalyzed enantioselective intramolecular addition of vinylpalladium species to ketones initiated by the carbopalladation of alkynoates under mild conditions without a Pd(II)/Pd(0) redox system was developed with high yield and enantioselectivity. This cascade reaction provides an efficient method for the construction of optically active hydroxylactones.
摘要
开发了一种阳离子钯（II）催化的对映选择性分子内反应，即在温和条件下，在没有Pd（II）/Pd（0）氧化还原体系的情况下，通过炔酸酯的碳钯化作用引发乙烯基钯物种与酮的加成反应，该反应具有高收率和对映选择性。这种串联反应为构建光学活性羟基内酯提供了一种有效方法。
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