损毁丘脑底核以减轻灵长类动物中1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病。
Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.
作者信息
Aziz T Z, Peggs D, Sambrook M A, Crossman A R
机构信息
Department of Cell and Structural Biology, University of Manchester Medical School, U.K.
出版信息
Mov Disord. 1991;6(4):288-92. doi: 10.1002/mds.870060404.
PMID:1758446
Abstract
Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.
摘要
MPTP 诱导的帕金森症神经机制的核心是丘脑底核活动过度。因此，已对两只患有这种病症的灵长类动物进行了丘脑底核损伤，结果发现该病症有显著改善。
Zotero 插件