Beaver Kevin M, Wright John Paul, DeLisi Matt, Walsh Anthony, Vaughn Michael G, Boisvert Danielle, Vaske Jamie
College of Criminology and Criminal Justice, Florida State University, Tallahassee, FL 32306-1127, USA.
Behav Brain Funct. 2007 Jun 22;3:30. doi: 10.1186/1744-9081-3-30.
Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene x gene interactions in the etiology of conduct disorder and antisocial behavior. This study examined whether adolescent conduct disorder and adult antisocial behavior were related to the dopamine D2 receptor polymorphism (DRD2) and the dopamine D4 receptor polymorphism (DRD4).
A sample of 872 male participants from the National Longitudinal Study of Adolescent Health (Add Health) completed self-report questionnaires that tapped adolescent conduct disorder and adult antisocial behavior. DNA was genotyped for DRD2 and DRD4.
Multivariate regression analysis revealed that neither DRD2 nor DRD4 had significant independent effects on conduct disorder or antisocial behavior. However, DRD2 interacted with DRD4 to predict variation in adolescent conduct disorder and in adult antisocial behavior.
The results suggest that a gene x gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.
反社会行为是复杂的多基因表型，由遗传多态性的多因素组合导致。然而，很少有实证研究考察品行障碍和反社会行为病因中的基因与基因相互作用。本研究考察青少年品行障碍和成人反社会行为是否与多巴胺D2受体多态性（DRD2）和多巴胺D4受体多态性（DRD4）有关。
来自青少年健康全国纵向研究（Add Health）的872名男性参与者样本完成了自我报告问卷，这些问卷涉及青少年品行障碍和成人反社会行为。对DRD2和DRD4进行基因分型。
多变量回归分析显示，DRD2和DRD4对品行障碍或反社会行为均无显著独立影响。然而，DRD2与DRD4相互作用，可预测青少年品行障碍和成人反社会行为的变异。
结果表明，DRD2和DRD4之间的基因与基因相互作用与男性品行障碍和成人反社会行为的发展有关。
