Mattei Agostino, Naspro Richard, Annino Filippo, Burke Daniel, Guida Romolo, Gaston Richard
Service d'Urologie, Clinique Saint Augustin, Bordeaux, France.
Eur Urol. 2007 Sep;52(3):687-94. doi: 10.1016/j.eururo.2007.05.029. Epub 2007 Jun 8.
To assess overall safety, histopathological outcomes, and early functional results after robotic-assisted laparoscopic radical prostatectomy (RALP) with a new lateral approach for the interfascial dissection of the neurovascular bundles without tension and any use of electrocautery.
Between April and September 2006, 100 consecutive patients with organ-confined prostate cancer (age < 70 yr, PSA < or = 10 microg/dl, Gleason score < or = 7, and IIEF > or = 17) underwent RALP by the same senior surgeon. Pre-, intra-, and perioperative data were recorded. The operative technique is described step by step. Patients were assessed at the 4-mo follow-up.
RALP was successfully completed in all patients. Neither blood transfusions nor reintervention were necessary. One week following catheter removal, complete early urinary continence was achieved in 80% of patients, and spontaneous erections or penile tumescence was reported by 46 patients. Positive surgical margins were 12.1% in the pT2 group and 29% in the pT3 group. Ninety-three patients were available for analysis at the 4-mo follow-up. Of them, 92.4% were completely continent, 5.4% used 1 pad a day, and 2.2% used 2 or more pads a day. Concerning the IIEF-EF domain score, 64.5% of the patients reported a total score > or = 17, and 17.2% of them scored > or = 26.
The novel approach described for RALP is safe and allows excellent dissection. It maintains good margin status and provides encouraging early continence and erectile functional results in selected patients. Long-term follow-up is necessary to assess the impact of this approach on oncological outcome.
评估采用一种新的外侧入路进行无张力且不使用电灼的神经血管束筋膜间分离的机器人辅助腹腔镜根治性前列腺切除术(RALP)后的总体安全性、组织病理学结果和早期功能结果。
2006年4月至9月期间,100例连续的器官局限性前列腺癌患者(年龄<70岁,PSA≤10μg/dl,Gleason评分≤7,国际勃起功能指数[IIEF]≥17)由同一位资深外科医生进行RALP手术。记录术前、术中及围手术期数据。逐步描述手术技术。在4个月随访时对患者进行评估。
所有患者均成功完成RALP手术。无需输血或再次干预。拔除导尿管1周后,80%的患者实现了早期完全尿控,46例患者报告有自发勃起或阴茎勃起。pT2组手术切缘阳性率为12.1%,pT3组为29%。93例患者在4个月随访时可进行分析。其中,92.4%的患者完全控尿,5.4%的患者每天使用1片尿垫,2.2%的患者每天使用2片或更多尿垫。关于IIEF-勃起功能(EF)领域评分,64.5%的患者报告总分≥17,其中17.2%的患者评分≥26。
所描述的RALP新方法是安全的,且能实现出色的分离。它能保持良好的切缘状态,并在部分患者中提供令人鼓舞的早期尿控和勃起功能结果。需要长期随访来评估该方法对肿瘤学结局的影响。