Morad N A, Ahmed M E, Al-Wabel A, Foli A K
Departments of Pathology and Medicine, College of Medicine, King Saud University, Abha, Saudi Arabia.
Ann Saudi Med. 1993 Jul;13(4):340-3. doi: 10.5144/0256-4947.1993.340.
The frequency of Helicobacter pylori (HP) infection in 208 patients with upper gastrointestinal tract symptoms from the Southern Province of Saudi Arabia was studied prospectively. The occurrence of HP was documented histologically and using a rapid urease test in antral endoscopic biopsies. Our results showed that 82.2% of the 208 patients included were positive for HP with a male:female ratio of approximately 1:1 (88:83). The age range was 14 to 80 years and the median age was 38.2 years. The frequencies of HP infection among Saudi and non-Saudi patients were 86% and 71%, respectively. Frequencies of HP infection were 88%, 77.5%, and 93% during the second, third, and fourth decades of life. Among the 140 patients with histologically proven antral gastritis, 128 cases (91%) were positive for HP whereas 29 cases (17%) of the 171 patients positive for HP did not show histologic evidence of antral gastritis. Our data showed that HP was present in 92.5% of patients with endoscopic diagnosis of duodenal ulceration, 81% of patients with duodenitis, 80% of patients with both duodenitis and gastritis, 69% of patients with gastric antral erythema, and 81% of patients with non-ulcer dyspepsia (normal upper gastrointestinal endoscopy). Histologically proven antral gastritis was seen in 80% of patients with endoscopic diagnosis of duodenal ulceration, 76% of patients with antral erythema, 70% of patients with both duodenitis and gastritis, 33% of patients with duodenitis only, and 66% of patients with non-ulcer dyspepsia. Among the 208 patients included in the study, gastric ulcerationw as only seen in two cases, both positive for HP.
对沙特阿拉伯南部省份208例有上消化道症状的患者幽门螺杆菌（HP）感染率进行了前瞻性研究。通过组织学检查并采用快速尿素酶试验对胃窦内镜活检组织进行检测，记录HP的感染情况。我们的研究结果显示，208例纳入研究的患者中，82.2%的患者HP检测呈阳性，男女比例约为1:1（88:83）。年龄范围为14至80岁，中位年龄为38.2岁。沙特患者和非沙特患者的HP感染率分别为86%和71%。在20岁至40岁年龄段，HP感染率分别为88%、77.5%和93%。在140例经组织学证实为胃窦炎的患者中，128例（91%）HP检测呈阳性，而在171例HP检测呈阳性的患者中，有29例（17%）未显示胃窦炎的组织学证据。我们的数据显示，在内镜诊断为十二指肠溃疡的患者中，92.5%存在HP；十二指肠炎症患者中，81%存在HP；同时患有十二指肠炎症和胃炎的患者中，80%存在HP；胃窦部红斑患者中，69%存在HP；非溃疡性消化不良（上消化道内镜检查正常）患者中，81%存在HP。在内镜诊断为十二指肠溃疡的患者中，80%经组织学证实为胃窦炎；胃窦部红斑患者中，76%经组织学证实为胃窦炎；同时患有十二指肠炎症和胃炎的患者中，70%经组织学证实为胃窦炎；仅患有十二指肠炎症的患者中，33%经组织学证实为胃窦炎；非溃疡性消化不良患者中，66%经组织学证实为胃窦炎。在纳入研究的208例患者中，仅2例出现胃溃疡，且均为HP阳性。
