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幽门螺杆菌感染及其与代谢综合征的关系:这是一个神话还是事实?

Helicobacter pylori infection and its relationship to metabolic syndrome: is it a myth or fact?

机构信息

Department of Internal Medicine, King Fahad Hospital of the University, Al-Khobar, Saudi Arabia.

出版信息

Saudi J Gastroenterol. 2011 May-Jun;17(3):165-9. doi: 10.4103/1319-3767.80377.

DOI:10.4103/1319-3767.80377
PMID:21546717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3122084/
Abstract

Metabolic syndrome is one of the most prevalent global health problems that predisposes to Type 2 diabetes. It is strongly linked to insulin resistance, which results in hyperglycemia. Over the past few years, lot of studies have been carried out on Helicobacter pylori infection and found a possible causal relationship through releasing some of the interleukins factors, which result in endothelial dysfunction. However, some studies attributed that due to coincidence were not able to establish any causal relationship. In this review, the literature has been reviewed to check this possible association.

摘要

代谢综合征是全球最普遍的健康问题之一,易导致 2 型糖尿病。它与胰岛素抵抗密切相关,后者会导致高血糖。在过去的几年中,已经进行了许多关于幽门螺杆菌感染的研究,并通过释放一些细胞因子发现了可能的因果关系,从而导致内皮功能障碍。但是,一些研究归因于巧合,未能建立任何因果关系。在这篇综述中,对文献进行了回顾,以检查这种可能的关联。

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本文引用的文献

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Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori.幽门螺杆菌CagA阳性菌株感染患者的冠状动脉粥样硬化负担
Coron Artery Dis. 2010 Jun;21(4):217-21. doi: 10.1097/MCA.0b013e3283399f36.
2
Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation.幽门螺杆菌根除对胰岛素抵抗、血脂及低度炎症的影响。
South Med J. 2010 Mar;103(3):190-6. doi: 10.1097/SMJ.0b013e3181cf373f.
3
Helicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population.幽门螺杆菌感染显著增加无症状日本人群的胰岛素抵抗。
Helicobacter. 2009 Oct;14(5):144-50. doi: 10.1111/j.1523-5378.2009.00705.x.
4
[Effects of Helicobacter pylori on blood glucose fluctuation in type 2 diabetic patients].[幽门螺杆菌对2型糖尿病患者血糖波动的影响]
Zhonghua Yi Xue Za Zhi. 2009 Apr 14;89(14):958-61.
5
Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population.幽门螺杆菌感染与日本人群的代谢综合征显著相关。
Am J Gastroenterol. 2008 Dec;103(12):3005-10. doi: 10.1111/j.1572-0241.2008.02151.x.
6
Seroprevalence of Helicobacter pylori Infection in Large Series of Patients in an Urban Area of Saudi Arabia.沙特阿拉伯某城市地区大量患者中幽门螺杆菌感染的血清流行率
Korean J Gastroenterol. 2008 Oct;52(4):226-9.
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Vascular risks and complications in diabetes mellitus: the role of helicobacter pylori infection.糖尿病中的血管风险与并发症:幽门螺杆菌感染的作用
J Stroke Cerebrovasc Dis. 2008 Mar-Apr;17(2):86-94. doi: 10.1016/j.jstrokecerebrovasdis.2007.10.006.
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Helicobacter pylori prevalence in diabetes mellitus patients with dyspeptic symptoms and its relationship to glycemic control and late complications.有消化不良症状的糖尿病患者中幽门螺杆菌的患病率及其与血糖控制和晚期并发症的关系。
Dig Dis Sci. 2008 Oct;53(10):2646-9. doi: 10.1007/s10620-007-0185-7. Epub 2008 Mar 5.
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Turk J Gastroenterol. 2007 Dec;18(4):225-9.