Morrow R H, Gutensohn N, Smith P G
Cancer Res. 1976 Feb;36(2 pt 2):667-9.
Infections with both Epstein-Barr virus (EBV) and malaria have been implicated as causal factors in the pathogenesis of Burkitt's lymphoma (BL). Proposed trials of preventive measures for both infections are receiving serious consideration as possible means of establishing a causal relationship with BL. In this paper we examine certain models for the interaction of EBV and malaria in the induction of BL, and also review the aims of the longitudinal, population-based study being conducted in the West Nile District of Uganda. Given existing knowledge, the outcome of preventive trials, even for the most simple interaction models, is unpredictable and, under certain circumstances, trials of an EBV vaccine could actually increase the incidence of BL. It is suggested that trials of an EBV vaccine at this time would be premature and should be delayed at least until the results from the West Nile prospective study are clear.
爱泼斯坦-巴尔病毒（EBV）感染和疟疾感染均被认为是伯基特淋巴瘤（BL）发病机制中的致病因素。针对这两种感染的预防措施的拟议试验正在作为与BL建立因果关系的可能手段而受到认真考虑。在本文中，我们研究了EBV和疟疾在诱导BL过程中相互作用的某些模型，并回顾了在乌干达西尼罗河地区进行的纵向、基于人群的研究的目标。鉴于现有知识，即使对于最简单的相互作用模型，预防性试验的结果也是不可预测的，并且在某些情况下，EBV疫苗试验实际上可能会增加BL的发病率。建议此时进行EBV疫苗试验为时过早，应至少推迟到西尼罗河前瞻性研究结果明确之后。
