Tavares B, Pereira C, Rodrigues F, Loureiro G, Chieira C
Immunoallergology Department, Coimbra University Hospitals, Coimbra, Portugal.
Allergol Immunopathol (Madr). 2007 May-Jun;35(3):113-6. doi: 10.1157/13106780.
Goat's milk (GM) allergy not associated with allergy to cow's milk (CM) is a rare disorder. Caseins have been implicated has the major allergens eliciting symptoms.
We report the case of a 27 years-old female patient that experienced two episodes of urticaria related to ingestion of goat's cheese (GC). She tolerated CM, dairy products and sheep cheese. Skin prick tests were performed with GM, CM, bovine casein and alpha -lactalbumin and fresh milk and GC. Serum specific IgE to GM, CM and its fractions, and GM and CM immunobloting assays with inhibition were also evaluated.
Skin tests were positive to GM and GC and negative to CM. GM immunoblot showed an IgE-binding 14 kDa band that was totally inhibited after serum pre-incubation with GM.
Allergens other than casein can be involved in allergy to GM. Even small quantities of protein can elicit symptoms.
与牛奶过敏无关的羊奶过敏是一种罕见的病症。酪蛋白被认为是引发症状的主要过敏原。
我们报告了一名27岁女性患者的病例，该患者因食用山羊奶酪（GC）经历了两次荨麻疹发作。她耐受牛奶、乳制品和绵羊奶酪。用羊奶、牛奶、牛酪蛋白、α-乳白蛋白、新鲜牛奶和山羊奶酪进行了皮肤点刺试验。还评估了针对羊奶、牛奶及其组分的血清特异性IgE，以及羊奶和牛奶的免疫印迹抑制试验。
皮肤试验对羊奶和山羊奶酪呈阳性，对牛奶呈阴性。羊奶免疫印迹显示一条14 kDa的IgE结合带，在用羊奶预孵育血清后完全被抑制。
除酪蛋白外的其他过敏原可能参与羊奶过敏。即使少量蛋白质也可引发症状。
