Tokuda T, Ikeda S, Yanagisawa N, Ihara Y, Glenner G G
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Acta Neuropathol. 1991;82(4):280-5. doi: 10.1007/BF00308813.
A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and also beta-protein immunoreactive senile plaques in the cortex. In the areas with many neurofibrillary tangles, neuropil threads with tau-immunoreactivity were also observed, and some of the senile plaque lesions were surrounded by abnormal neurites with tau-immunoreactivity. Moreover, three cases revealed beta-protein-type cerebrovascular amyloid deposits on both leptomeningeal and cortical blood vessels. The present observations indicate that the cerebral pathology of dementia pugilistica is very similar to that of Alzheimer's disease and suggest that these two disorders share some common etiological and pathogenic mechanisms.
利用传统组织学染色方法以及针对β-淀粉样蛋白和与PHF相关的tau蛋白的抗体进行免疫细胞化学，对8名前拳击手（年龄在56至83岁之间）的大脑进行了组织病理学研究。所有病例在皮质中均显示出大量tau免疫反应性神经原纤维缠结以及β-蛋白免疫反应性老年斑。在有许多神经原纤维缠结的区域，还观察到具有tau免疫反应性的神经毡丝，并且一些老年斑病变被具有tau免疫反应性的异常神经突所包围。此外，3例在软脑膜和皮质血管上均显示出β-蛋白型脑血管淀粉样沉积。目前的观察结果表明，拳击性痴呆的脑部病理与阿尔茨海默病非常相似，并提示这两种疾病具有一些共同的病因和发病机制。
