停止治疗后奈韦拉平在母乳中的持续存在情况。
Persistence of nevirapine in breast milk after discontinuation of treatment.
作者信息
Bennetto-Hood Chantelle, Aldrovandi Grace M, King Jennifer R, Woodman Kyra, Ashouri Negar, Acosta Edward P
机构信息
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-0019, USA.
出版信息
Clin Infect Dis. 2007 Aug 1;45(3):391-4. doi: 10.1086/519427. Epub 2007 Jun 18.
The objective of this study was to serially quantitate the concentration of nevirapine in breast milk after discontinuation of treatment. Samples were collected from both breasts of a human immunodeficiency virus-infected patient for 3 weeks. Nevirapine was quantifiable for up to 17 days after discontinuation of therapy; total nevirapine concentrations remained above the 90% inhibitory concentration for 6 days, and no differences were observed between breasts.
本研究的目的是在治疗中断后对母乳中奈韦拉平的浓度进行连续定量。从一名感染人类免疫缺陷病毒的患者双侧乳房采集样本，为期3周。治疗中断后，奈韦拉平在长达17天内可检测到；总奈韦拉平浓度在6天内保持高于90%抑制浓度，且双侧乳房之间未观察到差异。
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