Veerabadran Nalinkanth G, Goli Poorna L, Stewart-Clark Skylar S, Lvov Yuri M, Mills David K
Institute for Micromanufacturing, Louisiana Tech University, 911 Hergot Avenue, Ruston, Louisiana 71272, USA.
Macromol Biosci. 2007 Jul 9;7(7):877-82. doi: 10.1002/mabi.200700061.
Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications.
利用静电逐层组装技术，小鼠间充质干细胞已被聚（L - 赖氨酸）和透明质酸的聚电解质层单独包裹，形成了一个由厚度约为6 - 9纳米的纳米层组成的外壳。细胞形态和活力在长达一周的时间内得到了维持。对壳的渗透性和柔韧性进行进一步调整，将有助于这些封装细胞在组织工程和靶向递送应用中的使用。
