大剂量他莫昔芬治疗中的周边视网膜病变和黄斑病变
Peripheral retinopathy and maculopathy in high-dose tamoxifen therapy.
作者信息
Bourla Dan H, Sarraf David, Schwartz Steven D
机构信息
Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, California 90095, USA.
出版信息
Am J Ophthalmol. 2007 Jul;144(1):126-8. doi: 10.1016/j.ajo.2007.03.023.
PURPOSE
To describe the clinical, angiographic, and optical coherence tomography (OCT) features of high-dose tamoxifen retinopathy in three male patients.
DESIGN
Observational case series.
METHODS
A review of history, clinical examination, and findings on fluorescein angiography (FA) and optical coherence tomography (OCT) was conducted.
RESULTS
Three male patients receiving high-dose tamoxifen therapy sought treatment for vision loss and a crystalline maculopathy. Crystalline deposits were noted in the peripheral retina of two patients. All the patients showed macular leakage by FA, but cystoid macular edema (CME) on OCT was detected in two patients. Inner retinal hyperreflective deposits were identified by OCT in all the patients.
CONCLUSIONS
High-dose tamoxifen therapy may result in peripheral crystalline retinopathy in addition to perifoveal opacities. Angiographic evidence of macular edema may not unanimously correlate with presence of CME on OCT in these cases.
目的
描述三名男性患者高剂量他莫昔芬视网膜病变的临床、血管造影及光学相干断层扫描（OCT）特征。
设计
观察性病例系列。
方法
回顾病史、临床检查以及荧光素血管造影（FA）和光学相干断层扫描（OCT）的检查结果。
结果
三名接受高剂量他莫昔芬治疗的男性患者因视力丧失和结晶样黄斑病变前来就诊。两名患者的周边视网膜可见结晶样沉积物。所有患者荧光素血管造影均显示黄斑渗漏，但光学相干断层扫描检测到两名患者存在黄斑囊样水肿（CME）。所有患者光学相干断层扫描均发现视网膜内层高反射性沉积物。
结论
高剂量他莫昔芬治疗除可导致中心凹周围混浊外，还可能引起周边结晶样视网膜病变。在这些病例中，黄斑水肿的血管造影证据与光学相干断层扫描显示的黄斑囊样水肿不一定一致相关。
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