多西他赛视网膜病变：一例报告
Docetaxel Retinopathy: A Case Report.
作者信息
Nghiem-Buffet Sylvia, Cohen Salomon Yves, Giocanti-Auregan Audrey
机构信息
Centre d'Imagerie et de Laser, Paris, France; Ophthalmology Department, Vision and Handicaps, Avicenne Hospital, Bobigny, France.
Ophthalmology Department, Vision and Handicaps, Avicenne Hospital, Bobigny, France.
出版信息
Case Rep Ophthalmol. 2017 Jan 17;8(1):21-25. doi: 10.1159/000455088. eCollection 2017 Jan-Apr.
BACKGROUND
To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA).
CASE PRESENTATION
A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula. En-face OCT segmented at the inner retina showed the petaloid arrangement of cystic cavities, comparable to a cystoid ME.
CONCLUSIONS
The combined use of tamoxifen could have potentiated the toxic effect of docetaxel on the macula. En-face OCT images may reveal a petaloid aspect of the macula due to cysts in the inner retina segmentation, when FA shows no leakage.
背景
报告在一名接受多西他赛和他莫昔芬治疗的乳腺癌患者中使用表面光学相干断层扫描（OCT）检测黄斑水肿（ME），而荧光素血管造影（FA）未显示渗漏迹象。
病例介绍
一名接受乳腺癌治疗的52岁女性出现双侧视力丧失2个月。FA显示无明显渗漏，而双眼的光谱域OCT扫描显示在中等增厚的黄斑中有黄斑中心凹和黄斑旁囊性间隙。在内视网膜处分割的表面OCT显示囊性腔呈花瓣状排列，类似于囊样黄斑水肿。
结论
他莫昔芬的联合使用可能增强了多西他赛对黄斑的毒性作用。当FA显示无渗漏时，表面OCT图像可能由于内视网膜分割中的囊肿而显示黄斑的花瓣状外观。
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