日本眼附属器反应性淋巴样增生患者自身免疫性疾病的高发病率。
High incidence of autoimmune disease in Japanese patients with ocular adnexal reactive lymphoid hyperplasia.
作者信息
Kubota Toshinobu, Moritani Suzuko
机构信息
Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan.
出版信息
Am J Ophthalmol. 2007 Jul;144(1):148-9. doi: 10.1016/j.ajo.2007.03.018.
PURPOSE
To determine the incidence of autoimmune disease in Japanese patients with ocular adnexal lymphoid proliferations.
DESIGN
Case series study.
METHODS
The authors investigated the incidence of autoimmune disease in 88 patients with primary ocular adnexal lymphoid proliferations. Southern blot analysis was used to determine the presence of B-cell clonality in reactive lymphoid hyperplasia (RLH) associated with autoimmune disease.
RESULTS
Histopathologic analysis indicated that 15 (17%) patients had RLH, 62 (70%) patients had mucosa-associated lymphoid tissue lymphoma (MALToma), and 11 (13%) patients had primary lymphomas. The incidence of autoimmune disease was seven (47%) of 15 patients with RLH, two (3%) of 62 patients with MALToma, and zero (0%) of 11 patients with primary lymphoma. B-cell clonality was detected in one (14%) of seven RLH patients with autoimmune disease.
CONCLUSIONS
Ocular adnexal RLH with or without B-cell clonality is highly associated with autoimmune disease.
目的
确定日本眼部附属器淋巴样增生患者自身免疫性疾病的发病率。
设计
病例系列研究。
方法
作者调查了88例原发性眼部附属器淋巴样增生患者自身免疫性疾病的发病率。采用Southern印迹分析确定与自身免疫性疾病相关的反应性淋巴样增生（RLH）中B细胞克隆性的存在。
结果
组织病理学分析表明，15例（17%）患者为RLH，62例（70%）患者为黏膜相关淋巴组织淋巴瘤（MALToma），11例（13%）患者为原发性淋巴瘤。自身免疫性疾病的发病率在15例RLH患者中为7例（47%），在62例MALToma患者中为2例（3%），在11例原发性淋巴瘤患者中为0例（0%）。在7例患有自身免疫性疾病的RLH患者中有1例（14%）检测到B细胞克隆性。
结论
伴有或不伴有B细胞克隆性的眼部附属器RLH与自身免疫性疾病高度相关。
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