Gruenberger Birgit, Woehrer Stefan, Troch Marlene, Hauff Wolfgang, Lukas Julius, Streubel Berthold, Muellauer Leonhard, Chott Andreas, Raderer Markus
Department of Medicine I, Medical University Vienna, Vienna, Austria.
Acta Oncol. 2008;47(3):355-9. doi: 10.1080/02841860701630283.
A recent series from Italy has suggested a pathogenic link between hepatitis C virus and MALT lymphoma of the ocular adnexa. The hypothesis of our study was to prove this concept in Austrian patients with MALT lymphoma of the ocular adnexa.
A total of 45 patients presenting with MALT lymphoma of the ocular adnexa were assessed for the presence of infection with hepatitis A, B and C. Furthermore, extensive staging to evaluate the extent of disease along with analysis of Helicobacter pylori-infection, the presence or absence of autoimmune diseases (AD) and assessment of MALT-lymphoma specific genetic changes was performed.
Only 2/45 (4%) patients were tested positive for hepatitis C, while 10/45 (22%) had an underlying AD and 15/39 (38%) had HP infection. Chromosomal aberrations were detected in 19 (54%) of 35 patients analyzed. Disseminated disease was a significant risk factor for relapse (p=0.014).
Our series suggests that infection with hepatitis C is not a significant contributor to the pathogenesis of ocular adnexal MALT lymphoma in the Austrian population, while a substantial proportion of these patients suffer from autoimmune conditions.
意大利最近的一系列研究表明丙型肝炎病毒与眼附属器黏膜相关淋巴组织淋巴瘤之间存在致病联系。我们研究的假设是在奥地利眼附属器黏膜相关淋巴组织淋巴瘤患者中验证这一概念。
对45例眼附属器黏膜相关淋巴组织淋巴瘤患者进行了甲型、乙型和丙型肝炎感染情况评估。此外，还进行了广泛分期以评估疾病范围，同时分析幽门螺杆菌感染情况、自身免疫性疾病（AD）的有无以及黏膜相关淋巴组织淋巴瘤特异性基因变化。
仅2/45（4%）例患者丙型肝炎检测呈阳性，而10/45（22%）例患者患有潜在的自身免疫性疾病，15/39（38%）例患者有幽门螺杆菌感染。在35例分析患者中的19例（54%）检测到染色体畸变。疾病播散是复发的一个重要危险因素（p=0.014）。
我们的系列研究表明，在奥地利人群中，丙型肝炎感染并非眼附属器黏膜相关淋巴组织淋巴瘤发病机制的重要因素，而这些患者中有相当一部分患有自身免疫性疾病。
