Moslehi Roxana, Schymura Maria J, Nayak Seema, Coles F Bruce
Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, NY, USA ; Cancer Research Center, State University of New York at Albany, NY, USA.
Expert Rev Ophthalmol. 2011 Apr;6(2):181-193. doi: 10.1586/eop.11.15.
Ocular adnexal non-Hodgkin's lymphoma (NHL), the most common form of ophthalmic NHL, has a unique incidence pattern showing a steady and rapid increase in the past few decades, nearly equal rates among both genders, and predominance among Asians/Pacific Islanders. No major cause for ocular adnexal NHL has been identified, although infectious agents, immune disorders and genetic/epigenetic factors have all been implicated in its etiology. Identifying putative risk factors and biologic mechanisms leading to carcinogenesis in ocular adnexal NHL may enable implementation of effective preventive and/or therapeutic approaches for this malignancy. This article summarizes current knowledge on epidemiology of ocular adnexal NHL and the role of various potential risk factors in its etiology.
眼附属器非霍奇金淋巴瘤（NHL）是眼科NHL最常见的形式，具有独特的发病模式，在过去几十年中呈稳定且快速上升趋势，男女发病率几乎相等，在亚洲人/太平洋岛民中占主导地位。尽管感染因子、免疫紊乱以及遗传/表观遗传因素均被认为与其病因有关，但眼附属器NHL的主要病因尚未明确。确定导致眼附属器NHL发生癌变的假定危险因素和生物学机制，可能有助于实施针对这种恶性肿瘤的有效预防和/或治疗方法。本文总结了目前关于眼附属器NHL流行病学的知识以及各种潜在危险因素在其病因中的作用。
