Okoli Chizimuzo T C, Hall Lynne A, Rayens Mary Kay, Hahn Ellen J
University of British Columbia, Vancouver, British Columbia.
Biol Res Nurs. 2007 Jul;9(1):81-9. doi: 10.1177/1099800407300852.
This study assesses the validity of hair nicotine as a biomarker for secondhand smoke (SHS) exposure. Although most biomarkers of tobacco-smoke exposure have a relatively short half-life, hair nicotine can measure several months of cumulative SHS exposure.
A cross-sectional study of hospitality-industry workers.
Hair samples were obtained from 207 bar and restaurant workers and analyzed by the reversed-phase high-performance liquid chromatography with electrochemical detection (HPLC-ECD) method. Self-reported tobacco use and sources of SHS exposure were assessed.
Higher hair-nicotine levels were associated with more cigarettes smoked per day among smokers and a greater number of SHS-exposure sources among nonsmokers. Number of SHS exposure sources, gender, number of cigarettes smoked per day, and type of establishment predicted hair-nicotine levels.
Hair nicotine is a valid measure of SHS exposure. It may be used as an alternative biomarker to measure longer term SHS exposure.
本研究评估头发中的尼古丁作为二手烟暴露生物标志物的有效性。尽管大多数烟草烟雾暴露生物标志物的半衰期相对较短,但头发中的尼古丁可以测量数月的累积二手烟暴露情况。
对酒店业工人进行的横断面研究。
从207名酒吧和餐厅工作人员处采集头发样本,并采用反相高效液相色谱电化学检测法(HPLC-ECD)进行分析。评估自我报告的烟草使用情况和二手烟暴露来源。
头发中尼古丁水平较高与吸烟者每天吸烟数量较多以及非吸烟者二手烟暴露来源较多有关。二手烟暴露来源数量、性别、每天吸烟数量和场所类型可预测头发中尼古丁水平。
头发中的尼古丁是二手烟暴露的有效指标。它可作为一种替代生物标志物来测量长期二手烟暴露情况。