Müller R H, Petersen R D, Hommoss A, Pardeike J
Freie Universität Berlin, Department of Pharmaceutical Technology, Biopharmaceutics and NutriCosmetics, Kelchstrasse 31, 12169 Berlin, Germany.
Adv Drug Deliv Rev. 2007 Jul 10;59(6):522-30. doi: 10.1016/j.addr.2007.04.012. Epub 2007 May 17.
The first generation of lipid nanoparticles was introduced as solid lipid nanoparticles (SLN), the second, improved generation as nanostructured lipid carriers (NLC). Identical to the liposomes, the lipid nanoparticles (NLC) appeared as products first on the cosmetic market. The article gives an overview of the cosmetic benefits of lipid nanoparticles, that means enhancement of chemical stability of actives, film formation, controlled occlusion, skin hydration, enhanced skin bioavailability and physical stability of the lipid nanoparticles as topical formulations. NLC are on the market as concentrates to be used as cosmetic excipients, special formulation challenges for these products are discussed. NLC appeared also in a number of finished cosmetic products world-wide. An overview of these products is provided including their special effects due to the lipid nanoparticles, lipids used for their production and incorporated cosmetic actives.
第一代脂质纳米颗粒以固体脂质纳米粒（SLN）的形式出现，第二代改进型为纳米结构脂质载体（NLC）。与脂质体一样，脂质纳米颗粒（NLC）最初也是作为化妆品市场上的产品出现的。本文概述了脂质纳米颗粒的美容功效，即提高活性成分的化学稳定性、成膜、控制闭塞、皮肤保湿、提高皮肤生物利用度以及脂质纳米颗粒作为局部制剂的物理稳定性。NLC作为浓缩物在市场上用作化妆品辅料，文中讨论了这些产品面临的特殊配方挑战。NLC在全球范围内的许多成品化妆品中也有出现。本文提供了这些产品的概述，包括由于脂质纳米颗粒产生的特殊效果、用于生产它们的脂质以及所含的化妆品活性成分。
