Eichelberger Maryna C
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
Viral Immunol. 2007 Summer;20(2):243-9. doi: 10.1089/vim.2007.0017.
Influenza viruses continue to cause significant morbidity and mortality worldwide. With the threat of the emergence of a pandemic influenza strain, there is an urgency to develop new vaccine strategies that offer broad protection. The rational basis for the design of such vaccines comes from the use of animal models. Cotton rats are a helpful tool to study influenza disease pathogenesis and immunity because adaptation of human influenza strains is not required for virus replication in the lower respiratory tract and subsequent disease signs. This review describes innate and adaptive responses to influenza in infected cotton rats, and points out immune mechanisms that contribute to protection against disease.
流感病毒在全球范围内持续导致严重的发病和死亡。鉴于大流行性流感毒株出现的威胁，开发能提供广泛保护的新疫苗策略迫在眉睫。设计此类疫苗的合理依据源于动物模型的使用。棉鼠是研究流感疾病发病机制和免疫的有用工具，因为人类流感毒株在其下呼吸道复制及随后出现疾病体征并不需要适应过程。这篇综述描述了受感染棉鼠对流感的固有和适应性反应，并指出了有助于预防疾病的免疫机制。
