Blanco Jorge Cg, Boukhvalova Marina S, Perez Daniel R, Vogel Stefanie N, Kajon Adriana
Sigmovir Biosystems Inc. Rockville, USA.
Department of Veterinary Medicine, University of Maryland, Collage Park, USA.
J Antivir Antiretrovir. 2014 Mar 3;6:40-42. doi: 10.4172/jaa.1000093.
For over three decades, cotton rats have been a preferred model for human Respiratory Syncytial Virus (RSV) infection and pathogenesis, and a reliable model for an impressive list of human respiratory pathogens including adenoviruses, para influenza virus, measles, and human metapneumo virus. The most significant contribution of the cotton rat to biomedical research has been the development of anti-RSV antibodies for prophylactic use in high-risk infants. More recently, however, the cotton rat model has been further explored as a model for infection with other respiratory viral pathogens including influenza and rhinovirus.Together with RSV, these viruses inflict the greatest impact on the human respiratory health.This review will focus on the characteristics of these new models and their potential contribution to the development of new therapies.
三十多年来，棉鼠一直是人类呼吸道合胞病毒（RSV）感染和发病机制的首选模型，也是包括腺病毒、副流感病毒、麻疹和人偏肺病毒在内的众多人类呼吸道病原体的可靠模型。棉鼠对生物医学研究的最重要贡献是开发了用于高危婴儿预防的抗RSV抗体。然而，最近，棉鼠模型作为包括流感和鼻病毒在内的其他呼吸道病毒病原体感染的模型得到了进一步探索。这些病毒与RSV一起，对人类呼吸道健康造成了最大影响。本综述将重点关注这些新模型的特点及其对新疗法开发的潜在贡献。
