日本绿茶消费与口腔癌发病率的前瞻性研究。

A prospective study of green tea consumption and oral cancer incidence in Japan.

作者信息

Ide Reiko, Fujino Yoshihisa, Hoshiyama Yoshiharu, Mizoue Tetsuya, Kubo Tatsuhiko, Pham Truong-Minh, Shirane Kiyoyumi, Tokui Noritaka, Sakata Kiyomi, Tamakoshi Akiko, Yoshimura Takesumi

机构信息

Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyusyu, Japan.

出版信息

Ann Epidemiol. 2007 Oct;17(10):821-6. doi: 10.1016/j.annepidem.2007.04.003. Epub 2007 Jul 2.

DOI:10.1016/j.annepidem.2007.04.003

PMID:17606381

Abstract

PURPOSE

To examine the relation of green tea consumption with oral carcinogenesis, we prospectively analyzed data from a nationwide large-scale cohort study in Japan.

METHODS

A total of 20,550 men and 29,671 women aged 40-79 years, without any history of oral and pharyngeal cancer at baseline survey, were included in the present study. During a mean follow-up period of 10.3 years, 37 oral cancer cases were identified. The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) for oral cancer according to green tea consumption by sex, while adjusting for age, smoking, alcohol drinking, and other dietary factors.

RESULTS

For women, the HRs of oral cancer for green tea consumption of 1-2, 3-4, and 5 or more cups per day were 0.51 (95% CI: 0.10-2.68), 0.60 (95% CI: 0.17-2.10), and 0.31 (95% CI: 0.09-1.07), respectively, compared with those who drank less than one cup per day (p for trend, 0.08). For men, no such trends were observed.

CONCLUSIONS

Our findings did not suggest a prominent inverse association of green tea consumption with oral cancer, although there was a tendency for a reduced risk in women.

摘要

目的

为研究绿茶饮用量与口腔癌发生之间的关系，我们对日本一项全国性大规模队列研究的数据进行了前瞻性分析。

方法

本研究纳入了20550名年龄在40 - 79岁之间、基线调查时无口腔和咽癌病史的男性以及29671名女性。在平均10.3年的随访期内，共确诊37例口腔癌病例。采用Cox比例风险模型，在调整年龄、吸烟、饮酒及其他饮食因素后，按性别根据绿茶饮用量估计口腔癌的风险比（HR）和95%置信区间（95%CI）。

结果

对于女性，与每天饮用少于一杯绿茶的女性相比，每天饮用1 - 2杯、3 - 4杯以及5杯及以上绿茶的女性患口腔癌的HR分别为0.51（95%CI：0.10 - 2.68）、0.60（95%CI：0.17 - 2.10）和0.31（95%CI：0.09 - 1.07）（趋势p值为0.08）。对于男性，未观察到此类趋势。