Naganuma Toru, Kuriyama Shinichi, Kakizaki Masako, Sone Toshimasa, Nakaya Naoki, Ohmori-Matsuda Kaori, Nishino Yoshikazu, Fukao Akira, Tsuji Ichiro
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University School of Medicine, 2-1 Seiryo-machi Aoba-ku Sendai, 980-8575, Japan.
Am J Epidemiol. 2008 Dec 15;168(12):1425-32. doi: 10.1093/aje/kwn282. Epub 2008 Oct 29.
An inverse association between coffee consumption and the risk of oral, pharyngeal, and esophageal cancers has been suggested in case-control studies, but few results from prospective studies are available. Data from the Miyagi Cohort Study in Japan were used to clarify the association between coffee consumption and the risk of these cancers. Information about coffee consumption was obtained from self-administered food frequency questionnaires in 1990. Among 38,679 subjects aged 40-64 years with no previous history of cancer, 157 cases of oral, pharyngeal, and esophageal cancers were identified during 13.6 years of follow-up. Hazard ratios were estimated by the Cox proportional hazards regression model. The risk of oral, pharyngeal, and esophageal cancers was inversely associated with coffee consumption. The multivariate-adjusted hazard ratio of these cancers for > or =1 cups of coffee per day compared with no consumption was 0.51 (95% confidence interval: 0.33, 0.77). This inverse association was consistent regardless of sex and cancer site and was observed both for subjects who did not drink or smoke and for those who currently drank or smoked at baseline. In conclusion, coffee consumption was associated with a lower risk of oral, pharyngeal, and esophageal cancers, even in the group at high risk of these cancers.
病例对照研究表明咖啡摄入量与口腔癌、咽癌和食管癌风险之间存在负相关，但前瞻性研究的相关结果较少。日本宫城队列研究的数据被用于阐明咖啡摄入量与这些癌症风险之间的关联。1990年通过自填式食物频率问卷获取咖啡摄入信息。在38679名年龄在40 - 64岁且无癌症病史的受试者中，在13.6年的随访期间确诊了157例口腔癌、咽癌和食管癌病例。通过Cox比例风险回归模型估计风险比。口腔癌、咽癌和食管癌的风险与咖啡摄入量呈负相关。与不喝咖啡相比，每天饮用≥1杯咖啡的这些癌症的多变量调整风险比为0.51（95%置信区间：0.33, 0.77）。无论性别和癌症部位如何，这种负相关都是一致的，并且在基线时不饮酒或不吸烟的受试者以及当前饮酒或吸烟的受试者中均观察到。总之，即使在这些癌症的高危人群中，咖啡摄入也与较低的口腔癌、咽癌和食管癌风险相关。
