Naganuma Toru, Kuriyama Shinichi, Kakizaki Masako, Sone Toshimasa, Nakaya Naoki, Ohmori-Matsuda Kaori, Hozawa Atsushi, Nishino Yoshikazu, Tsuji Ichiro
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University School of Medicine, Miyagi, Japan.
Am J Epidemiol. 2009 Sep 15;170(6):730-8. doi: 10.1093/aje/kwp187. Epub 2009 Jul 29.
Several biologic studies have reported that green tea constituents have antitumor effects on hematologic malignancies. However, the effects in humans are uncertain. The authors used data from the Ohsaki National Health Insurance Cohort Study in Japan to evaluate the association between green tea consumption and the risk of hematologic malignancies. Study participants were 41,761 Japanese adults aged 40-79 years without a history of cancer at baseline who answered a food frequency questionnaire survey in 1994. During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. Hazard ratios were calculated by using the Cox proportional hazards regression model. Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). The corresponding risk estimate was 0.52 (95% confidence interval: 0.31, 0.87) for lymphoid neoplasms and 0.76 (95% confidence interval: 0.32, 1.78) for myeloid neoplasms. This inverse association was consistent across sex and body mass index strata. In conclusion, green tea consumption was associated with a lower risk of hematologic malignancies.
多项生物学研究报告称，绿茶成分对血液系统恶性肿瘤具有抗肿瘤作用。然而，其对人类的影响尚不确定。作者利用日本大崎国民健康保险队列研究的数据，评估绿茶消费与血液系统恶性肿瘤风险之间的关联。研究参与者为41761名40 - 79岁的日本成年人，他们在基线时无癌症病史，并于1994年回答了一份食物频率问卷调查。从1995年开始的9年随访期间，作者记录了157例血液系统恶性肿瘤，包括119例淋巴肿瘤和36例髓系肿瘤。使用Cox比例风险回归模型计算风险比。血液系统恶性肿瘤风险与绿茶消费呈负相关。每天饮用5杯或更多绿茶与每天饮用少于1杯绿茶相比，血液系统恶性肿瘤的多变量调整风险比为0.58（95%置信区间：0.37, 0.89）。淋巴肿瘤的相应风险估计为0.52（95%置信区间：0.31, 0.87），髓系肿瘤为0.76（95%置信区间：0.32, 1.78）。这种负相关在性别和体重指数分层中是一致的。总之，饮用绿茶与较低的血液系统恶性肿瘤风险相关。
