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从伊朗皮肤利什曼病患者中分离出的对葡糖胺锑钠耐药的热带利什曼原虫对其他抗利什曼原虫药物敏感。

Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs.

作者信息

Hadighi R, Boucher P, Khamesipour A, Meamar A R, Roy G, Ouellette M, Mohebali M

机构信息

Department of Parasitology, Faculty of Medicine, Iran University of Medical Sciences, 14496, Tehran, Iran.

出版信息

Parasitol Res. 2007 Oct;101(5):1319-22. doi: 10.1007/s00436-007-0638-0. Epub 2007 Jul 5.

DOI:10.1007/s00436-007-0638-0
PMID:17610079
Abstract

Cutaneous leishmaniasis (CL) is a major health problem in endemic areas of Iran. The pentavalent antimony (SbV) based drug Glucantime is the first line of treatment for CL in Iran, but recently SbV-resistant Leishmania tropica isolates derived from unresponsive patients were reported. We show in this study that these resistant parasites are cross-resistant to the other SbV-containing drug Pentostam and at least for one isolate also to amphotericin B. However, these resistant isolates were shown to be sensitive to miltefosine and paromomycin. The latter two drugs could thus be useful alternatives for the treatment of leishmaniasis in Iran even for SbV-resistant isolates.

摘要

皮肤利什曼病（CL）是伊朗流行地区的一个主要健康问题。基于五价锑（SbV）的药物葡糖酸锑钠是伊朗治疗CL的一线药物，但最近有报道称，从无反应患者中分离出了对SbV耐药的热带利什曼原虫。我们在本研究中表明，这些耐药寄生虫对另一种含SbV的药物喷他脒呈交叉耐药，并且至少对一株分离株而言，对两性霉素B也呈交叉耐药。然而，这些耐药分离株对米替福新和巴龙霉素敏感。因此，后两种药物即使对于对SbV耐药的分离株，也可能是治疗伊朗利什曼病的有用替代药物。

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本文引用的文献

[1]
A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

Mol Cell Proteomics. 2007-1

[2]
American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility?

J Infect Dis. 2006-10-15

[3]
Resistance to antimony and treatment failure in human Leishmania (Viannia) infection.

J Infect Dis. 2006-5-15

[4]
Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites.

PLoS Med. 2006-5

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Clin Microbiol Rev. 2006-1

[6]
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Antimicrob Agents Chemother. 2006-1

[7]
Characterization of Leishmania infection in rodents from endemic areas of the Islamic Republic of Iran.

East Mediterr Health J. 2004

[8]
Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004.

Lancet Infect Dis. 2005-12

[9]
Advances in leishmaniasis.

Lancet. 2005

[10]
Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal.

Antimicrob Agents Chemother. 2005-11

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