普拉地诺内酯B的立体化学
Stereochemistry of pladienolide B.
作者信息
Asai Naoki, Kotake Yoshihiko, Niijima Jun, Fukuda Yoshio, Uehara Taisuke, Sakai Takashi
机构信息
Tsukuba Research Laboratories, Eisai Co., Ltd, Tokodai, Tsukuba, Ibaraki, Japan.
出版信息
J Antibiot (Tokyo). 2007 Jun;60(6):364-9. doi: 10.1038/ja.2007.49.
PMID:17617693
Abstract
Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.
摘要
普拉地诺醇B是一种从浅蓝链霉菌Mer-11107中分离得到的12元大环内酯类化合物。它在体外和体内均显示出强大的抗肿瘤活性，是新型抗肿瘤药物的潜在先导化合物。基于普拉地诺醇B及其化学转化产物的光谱数据确定了十个手性中心的绝对构型。
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