Ishi K, Shimota H, Kawashima T, Kawahata S, Kubota T, Takada M
Department of Clinical Laboratory, Juntendo Urayasu Hospital, Juntendo University, School of Medicine, Urayasu.
Rinsho Byori. 1991 Nov;39(11):1215-9.
Kits for measurement of C. trachomatis specific antibody are not commercially available, but of the significance of determination of the serum antibody level has not been clarified. In this study, we first determined the C. trachomatis antibody level in patients considered to be free of C. trachomatis infection. Then, we evaluated the relationship between the presence or absence of antigen with the antibody level in patients at our department who were available for antigen examination. Anti-C. trachomatis IgA and IgG antibodies were detected in all age groups with a peak frequency in the 20's expect that IgA antibody was absent in the umbilical blood (IgG antibody was detected also in the umbilical blood). Concerning the relationship between the presence or absence of C. trachomatis antigen and the serum antibody levels, both IgA and IgG antibodies were significantly different (chi 2 test, p less than 0.01) between the antigen-positive group and the antigen-negative group. Because females infected by C. trachomatis were more often asymptomatic than infected males, and because antigen tests may produce false negative results, determination of the antibody level must be included in the clinical tests. Determination of the antibody level is considered to be valuable also in screening for mother-child infection and asymptomatic infection.
用于检测沙眼衣原体特异性抗体的试剂盒尚无商业供应，但血清抗体水平测定的意义尚未阐明。在本研究中，我们首先测定了被认为无沙眼衣原体感染患者的沙眼衣原体抗体水平。然后，我们评估了在本部门可进行抗原检测的患者中，抗原的有无与抗体水平之间的关系。在所有年龄组中均检测到抗沙眼衣原体IgA和IgG抗体，20多岁年龄组出现频率最高，但脐血中未检测到IgA抗体（脐血中也检测到了IgG抗体）。关于沙眼衣原体抗原的有无与血清抗体水平之间的关系，抗原阳性组和抗原阴性组之间的IgA和IgG抗体均有显著差异（χ²检验，p<0.01）。由于感染沙眼衣原体的女性比感染男性更常无症状，且由于抗原检测可能产生假阴性结果，因此抗体水平的测定必须纳入临床检测。抗体水平的测定在母婴感染和无症状感染的筛查中也被认为是有价值的。
