Uchino A, Noguchi T, Nomiyama K, Takase Y, Nakazono T, Nojiri J, Kudo S
Department of Radiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Neuroradiology. 2007 Sep;49(9):715-20. doi: 10.1007/s00234-007-0243-z. Epub 2007 Jul 12.
Manganese (Mn) accumulation in the brain is detected as symmetrical high signal intensity in the globus pallidi on T1-weighted MR images without an abnormal signal on T2-weighted images. In this review, we present several cases of Mn accumulation in the brain due to acquired or congenital diseases of the abdomen including hepatic cirrhosis with a portosystemic shunt, congenital biliary atresia, primary biliary cirrhosis, congenital intrahepatic portosystemic shunt without liver dysfunction, Rendu-Osler-Weber syndrome with a diffuse intrahepatic portosystemic shunt, and patent ductus venosus. Other causes of Mn accumulation in the brain are Mn overload from total parenteral nutrition and welding-related Mn intoxication.
在T1加权磁共振成像上，大脑中锰（Mn）的蓄积表现为苍白球对称的高信号强度，而在T2加权图像上无异常信号。在本综述中，我们介绍了几例因腹部获得性或先天性疾病导致大脑锰蓄积的病例，这些疾病包括伴有门体分流的肝硬化、先天性胆道闭锁、原发性胆汁性肝硬化、无肝功能障碍的先天性肝内门体分流、伴有弥漫性肝内门体分流的遗传性出血性毛细血管扩张症以及静脉导管未闭。大脑锰蓄积的其他原因包括全胃肠外营养导致的锰过载以及与焊接相关的锰中毒。
