对氧磷酶1基因与患阿尔茨海默病风险的关联研究。
Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease.
作者信息
Chapuis Julien, Boscher Maud, Bensemain Faiza, Cottel Dominique, Amouyel Philippe, Lambert Jean-Charles
机构信息
INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France.
出版信息
Neurobiol Aging. 2009 Jan;30(1):152-6. doi: 10.1016/j.neurobiolaging.2007.05.021. Epub 2007 Jul 12.
Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.
最近，在一个大型泛种族（白种人和非裔美国人）数据集中，对氧磷酶1基因（PON1）启动子和内含子1区域与患阿尔茨海默病（AD）的风险相关。我们试图在一项针对散发病例和对照的大型法国研究中重复这一观察结果。我们证实，PON1基因的近端启动子和5'序列可能存在与患AD风险相关的未知功能变异。
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