Saeidi Mohsen, Shakeri Raheleh, Marjani Abdoljalal, Khajeniazi Safoura
Stem Cell Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran.
Student Research Committee, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran.
Open Biochem J. 2017 Jun 13;11:47-55. doi: 10.2174/1874091X01711010047. eCollection 2017.
Some studies have indicated that human paraoxonase 1 () activity shows a polymorphic distribution. The aim of this study was to determine the distribution of polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group.
The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of were determined.
There were significant differences in distribution of genotypes and alleles among patients and control group. The most common genotype was CT in patients and control group, while the most frequent alleles were T and C in patients and controls, respectively. There was a statistically significant variation between serum activity and -108C> T polymorphism. The highest enzyme activities in the patients and controls were found in CC, while lower enzyme activities were seen in CT and TT genotypes in both genders and age groups.
Onset of Alzheimer's disease may depend on different polymorphisms of the enzyme. Late or early-onset of Alzheimer's disease may also depend on age and gender distribution, especially for arylesterase enzyme. Further studies on polymorphism of the enzyme are necessary for interpretation of possible polymorphic effects of enzyme on activity in humans.
一些研究表明，人对氧磷酶1（）活性呈多态性分布。本研究旨在确定戈尔甘地区阿尔茨海默病患者中多态性的分布情况，并与健康对照组进行比较。
该研究纳入了100名健康个体和50名患者。测定了的酶活性和基因多态性。
患者组和对照组之间的基因型和等位基因分布存在显著差异。患者组和对照组中最常见的基因型均为CT，而患者组和对照组中最常见的等位基因分别为T和C。血清活性与-108C>T多态性之间存在统计学上的显著差异。患者组和对照组中CC基因型的酶活性最高，而CT和TT基因型在各性别和年龄组中的酶活性较低。
阿尔茨海默病的发病可能取决于该酶的不同多态性。阿尔茨海默病的迟发或早发也可能取决于年龄和性别分布，尤其是对于芳基酯酶。有必要对该酶的多态性进行进一步研究，以解释该酶对人类活性可能产生的多态性影响。
