Tsukiji Miwako, Watanabe Nozomi, Yamaura Yasuko, Okahashi Noriko, Obase Kikuko, Neishi Yoji, Toyota Eiji, Kawamoto Takahiro, Okura Hiroyuki, Ogasawara Yasuo, Yoshida Kiyoshi
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan.
J Am Soc Echocardiogr. 2008 Jan;21(1):43-6. doi: 10.1016/j.echo.2007.05.023. Epub 2007 Jul 12.
We investigated the degree of mitral valve coaptation with a custom quantitation software system using transthoracic three-dimensional (3D) echocardiography. With real-time 3D echocardiography, we obtained transthoracic volumetric images in 20 healthy subjects and 20 patients with dilated cardiomyopathy. With our novel software system, the surface area of mitral valve tenting in the onset of mitral leaflet closure [O] and the timing of maximum closure of mitral leaflet [M] were reconstructed for quantitative measurement. The coaptation index was calculated by the following formula: [(3D tenting surface area in O-3D tenting surface area in M)/3D tenting surface area in O]. The coaptation index in patients with dilated cardiomyopathy was significantly smaller than that in healthy subjects (11% +/- 4.1% vs. 18% +/- 8.0%, P = .004). The custom quantitation software system with 3D echocardiography allowed us to assess the degree of mitral valve coaptation.
我们使用经胸三维（3D）超声心动图，通过一个定制的定量软件系统研究二尖瓣瓣叶对合程度。利用实时3D超声心动图，我们获取了20名健康受试者和20名扩张型心肌病患者的经胸容积图像。通过我们的新型软件系统，重建二尖瓣叶关闭起始点[O]处二尖瓣瓣叶膨出的表面积以及二尖瓣叶最大关闭时刻[M]，进行定量测量。对合指数通过以下公式计算：[(O点的3D膨出表面积 - M点的3D膨出表面积)/O点的3D膨出表面积]。扩张型心肌病患者的对合指数显著小于健康受试者（11%±4.1%对18%±8.0%，P = .004）。带有3D超声心动图的定制定量软件系统使我们能够评估二尖瓣瓣叶对合程度。
