检测磷脂双分子层两半之间的串扰。
Detecting cross talk between two halves of a phospholipid bilayer.
作者信息
Zhang Jianbing, Jing Bingwen, Janout Vaclav, Regen Steven L
机构信息
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
出版信息
Langmuir. 2007 Aug 14;23(17):8709-12. doi: 10.1021/la701503v. Epub 2007 Jul 13.
Abstract
One of the most challenging questions that relates to the structure and function of biological membranes is whether the two halves of the bilayer "talk" to each other. In this letter, we show how the perturbation of the lateral organization of one leaflet of a fluid phospholipid bilayer by an external agent also alters the lateral organization of the adjoining leaflet. In addition, we show that the energy involved in such "cross talk" corresponds to ca. 100 cal/mol of phospholipid. These findings provide a basis for expecting similar cross talk to exist in cell membranes.
摘要
与生物膜的结构和功能相关的最具挑战性的问题之一是，双层膜的两个半叶是否相互“交流”。在这封信中，我们展示了外部因素对流体磷脂双层一个小叶的横向组织的扰动如何也改变相邻小叶的横向组织。此外，我们表明，这种“串扰”所涉及的能量约为每摩尔磷脂100卡。这些发现为预期细胞膜中存在类似的串扰提供了依据。
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