石刁柏中的甾体皂苷和蜕皮甾酮及其细胞毒性活性。
Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities.
机构信息
Key Laboratory of Modern Chinese Medicine, China Pharmaceutical University, Nanjing 210009, PR China.
出版信息
Steroids. 2010 Oct;75(10):734-9. doi: 10.1016/j.steroids.2010.05.002. Epub 2010 May 12.
Two new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 1-10 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 8-10 exhibited cytotoxic activities with IC(50) values ranging from 3.4 to 6.6microM.
两种新的螺甾烷醇类化合物，菲利亚沙泊苷 E（1）和 F（2），一种新的呋甾烷醇苷，菲利亚沙泊苷 G（3），以及一种新的蜕皮甾酮，20,22-乙酰基-薯蓣甾酮 A（4），连同 6 种已知的甾体皂苷，天门冬酰胺 A（5），菲利亚沙泊苷 A（6），菲利亚沙泊苷 B（7）， asparagoside A（8）， asparagoside B（9）和菲利亚沙泊苷 C（10），从天门冬属植物的根中分离得到。根据光谱和化学证据，确定了它们的结构。对化合物 1-10 进行了对人乳腺癌 MDA-MB-231 细胞系的细胞毒性测试，化合物 8-10 显示出细胞毒性活性，IC（50）值范围为 3.4 至 6.6μM。
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