Sepehr Amin, Miri Seyedeh Tina, Aghamohammad Shadi, Rahimirad Nazanin, Milani Mahnaz, Pourshafie Mohammad-Reza, Rohani Mahdi
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Department of Microbiology, Islamic Azad University Science and Research Branch, Tehran, Iran.
Medicine (Baltimore). 2024 Dec 27;103(52):e32412. doi: 10.1097/MD.0000000000032412.
Gut microbiota and its metabolic activities can influence the physiology and pathology of the human body. It is well established that alterations in the balance of living microbiota can contribute to various health problems, such as inflammatory bowel disease and autoimmune disorders. Probiotics administered in sufficient quantities as functional food ingredients provide health benefits to hosts. They help to maintain the stability and composition of the gut microbiota and provide resistance to infection by pathogens. The most important probiotic bacteria are Lactobacillus spp. and Bifidobacteria spp., which protect the intestine through various mechanisms such as the production of organic acids and bacteriocins. Scientific and clinical research has demonstrated that probiotics play a role in modulating immune response and preventing cancer and chronic inflammatory diseases, especially in the gastrointestinal tract. This article summarizes the potential health benefits, antimicrobial activities, and purposes for which probiotics can be used as functional foods to improve human health.
肠道微生物群及其代谢活动会影响人体的生理和病理状态。众所周知，活微生物群平衡的改变会导致各种健康问题，如炎症性肠病和自身免疫性疾病。作为功能性食品成分足量施用的益生菌对宿主有益健康。它们有助于维持肠道微生物群的稳定性和组成，并提供对病原体感染的抵抗力。最重要的益生菌是乳酸杆菌属和双歧杆菌属，它们通过产生有机酸和细菌素等多种机制保护肠道。科学和临床研究表明，益生菌在调节免疫反应、预防癌症和慢性炎症性疾病方面发挥作用，尤其是在胃肠道。本文总结了益生菌作为功能性食品改善人类健康的潜在健康益处、抗菌活性及用途。
