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A Massachusetts prototype like coronavirus isolated from wild peafowls is pathogenic to chickens.

作者信息

Sun Lei, Zhang Gui-Hong, Jiang Jing-Wei, Fu Jia-Dong, Ren Tao, Cao Wei-Sheng, Xin Chao-An, Liao Ming, Liu Wen-Jun

机构信息

Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China.

出版信息

Virus Res. 2007 Dec;130(1-2):121-8. doi: 10.1016/j.virusres.2007.06.003. Epub 2007 Jul 13.

DOI:10.1016/j.virusres.2007.06.003
PMID:17629993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7114154/
Abstract

Coronavirus infection was investigated in apparently healthy wild peafowls in Guangdong province of China in 2003, while severe acute respiratory syndrome (SARS) broke out there. No SARS-like coronavirus had been isolated but a novel avian coronavirus strain, Peafowl/GD/KQ6/2003 (KQ6), was identified. Sequence analysis revealed that KQ6 was an avian coronavirus infectious bronchitis virus (IBV), a member of coronavirus in group 3. The genome sequence of KQ6 had extremely high degree of identity with that of a Massachusetts prototype IBV M41. KQ6 was pathogenic to chickens but non-pathogenic to peafowls under experimental conditions. Seventeen out of fifty-four (31.48%) peafowl serum samples were tested positive for specific antibodies against IBV. Present results indicate that the peafowl isolate KQ6 is a Massachusetts prototype like coronavirus strain which undergoes few genetic changes and peafowl might have acted as a natural reservoir of IBV for very long time.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/7114154/7f2d7f4c4db6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/7114154/e22550fa1850/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/7114154/7f2d7f4c4db6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/7114154/e22550fa1850/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/7114154/7f2d7f4c4db6/gr2.jpg

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Avian Pathol. 2000 Jun;29(3):207-12. doi: 10.1080/03079450050045459.
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Avian Pathol. 2005 Dec;34(6):439-48. doi: 10.1080/03079450500367682.
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