来源于软珊瑚内生真菌 SCSIO 41031 的环肽
Cyclic Peptides from the Soft Coral-Derived Fungus SCSIO 41031.
机构信息
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Mar Drugs. 2021 Dec 10;19(12):701. doi: 10.3390/md19120701.
Three novel cyclic hexapeptides, sclerotides C-E (-), and a new lipodepsipeptide, scopularide I (), together with a known cyclic hexapeptide sclerotide A (), were isolated from fermented rice cultures of a soft coral-derived fungus: SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey's method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I () exhibited acetylcholinesterase inhibitory activity with an IC value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC value of 10.1 μM.
从软珊瑚来源真菌 SCSIO 41031 的发酵大米培养物中分离得到三个新的环六肽，即 sclerotides C-E(-)，以及一个新的脂肽 scopularide I()，同时还分离得到一个已知的环六肽 sclerotide A()。新肽的结构通过 1D 和 2D NMR 波谱分析、Marfey 法、ESIMS/MS 分析和单晶 X 射线衍射分析确定。Scopularide I()对乙酰胆碱酯酶表现出抑制活性，IC 值为 15.6 μM，对人鼻咽癌细胞系 HONE-EBV 表现出较弱的细胞毒性，IC 值为 10.1 μM。
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