Falsey Ann R
Division of Infectious Diseases, Department of Medicine at Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA.
Clin Geriatr Med. 2007 Aug;23(3):535-52, vi. doi: 10.1016/j.cger.2007.02.002.
Advanced age often is associated with functional and immunologic decline and chronic cardiopulmonary diseases that predispose to pneumonia when viral infection occurs. Influenza virus remains the primary viral pathogen in the elderly, although the impact of the other respiratory viruses remains to be defined. The clinical syndromes associated with respiratory viruses frequently are indistinguishable from one another or bacterial pathogens; often, viral illness in older adults exacerbates underlying conditions, complicating diagnosis. Antiviral therapy is available for influenza A and B; specific viral diagnosis, particularly with the use of rapid antigen detection, may be useful for clinical management. Treatment for other viruses primarily is supportive.
高龄往往与功能和免疫功能衰退以及慢性心肺疾病相关,这些疾病在发生病毒感染时易引发肺炎。流感病毒仍是老年人中的主要病毒病原体,尽管其他呼吸道病毒的影响尚待明确。与呼吸道病毒相关的临床综合征通常彼此难以区分,也与细菌病原体难以区分;老年人的病毒感染常常会加重基础疾病,使诊断变得复杂。甲型和乙型流感有抗病毒治疗方法;进行特异性病毒诊断,尤其是使用快速抗原检测,可能对临床管理有用。对其他病毒的治疗主要是支持性治疗。