Laboratory of Medical Microbiology and Immunology, St Elisabeth Hospital, Tilburg, The Netherlands.
Influenza Other Respir Viruses. 2013 Jul;7(4):567-73. doi: 10.1111/j.1750-2659.2012.00425.x. Epub 2012 Aug 22.
Modern molecular techniques reveal new information on the role of respiratory viruses in community-acquired pneumonia. In this study, we tried to determine the prevalence of respiratory viruses and bacteria in patients with community-acquired pneumonia who were admitted to the hospital.
Between April 2008 and April 2009, 408 adult patients (aged between 20 and 94 years) with community-acquired pneumonia were tested for the presence of respiratory pathogens using bacterial cultures, real-time PCR for viruses and bacteria, urinary antigen testing for Legionella and Pneumococci and serology for the presence of viral and bacterial pathogens.
Pathogens were identified in 263 (64·5%) of the 408 patients. The most common single organisms in these 263 patients were Streptococcus pneumoniae (22·8%), Coxiella burnetii (6·8%) and influenza A virus (3·8%). Of the 263 patients detected with pathogens, 117 (44·5%) patients were positive for one or more viral pathogens. Of these 117 patients, 52 (44·4%) had no bacterial pathogen. Multiple virus infections (≥2) were found in 16 patients.
In conclusion, respiratory viruses are frequently found in patients with CAP and may therefore play an important role in the aetiology of this disease.
现代分子技术揭示了呼吸道病毒在社区获得性肺炎中的作用的新信息。在这项研究中，我们试图确定住院社区获得性肺炎患者中呼吸道病毒和细菌的流行情况。
2008 年 4 月至 2009 年 4 月期间，对 408 例年龄在 20 至 94 岁之间的成人社区获得性肺炎患者使用细菌培养、病毒和细菌实时 PCR、尿抗原检测军团菌和肺炎球菌以及血清学检测病毒和细菌病原体来检测呼吸道病原体的存在。
在 408 例患者中，有 263 例（64.5%）确定了病原体。在这 263 例患者中，最常见的单一病原体是肺炎链球菌（22.8%）、伯纳特立克次体（6.8%）和甲型流感病毒（3.8%）。在检测到病原体的 263 例患者中，117 例（44.5%）患者有一个或多个病毒病原体阳性。在这 117 例患者中，52 例（44.4%）无细菌病原体。16 例患者存在多种病毒感染（≥2）。
总之，呼吸道病毒在 CAP 患者中经常被发现，因此可能在该疾病的发病机制中发挥重要作用。
