Pomelov V S, Zhumalilov Zh Sh, Korotkina R N, Karelin A A
Sov Med. 1991(8):27-30.
It is shown that in acute cholecystitis patients versus chronic cholecystitis ones and donors, the total glutathione in blood is lower while the activity of glutathione metabolism enzymes in red blood cells inhibited. Enzymological findings correlate with clinical symptoms of intoxication. Surgery aggravates disturbed activity of the enzymes. Conventional conservative therapy is not effective in normalizing the enzymes activity either. A good therapeutic response can be achieved by a directed transport of antibiotics in autologous blood ghosts which promotes recovery of normal activity of glutathione metabolism enzymes, routine glutathione level, early stabilization of hepatocytic membranes beneficial for surgical patients.
结果表明，与慢性胆囊炎患者及捐献者相比，急性胆囊炎患者血液中的总谷胱甘肽含量较低，而红细胞中谷胱甘肽代谢酶的活性受到抑制。酶学检查结果与中毒的临床症状相关。手术会加重酶活性的紊乱。传统的保守治疗也无法有效使酶活性恢复正常。通过将抗生素定向转运至自体血影中可获得良好的治疗效果，这有助于谷胱甘肽代谢酶的正常活性恢复、恢复常规谷胱甘肽水平，并使肝细胞膜早期稳定，对手术患者有益。
