Lane Mark A, Roth George S, Ingram Donald K
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Methods Mol Biol. 2007;371:143-9. doi: 10.1007/978-1-59745-361-5_11.
Caloric restriction remains the only nongenetic intervention that has been consistently and reproducibly shown to extend both average and maximal lifespan in a wide variety of species. If shown to be applicable to human aging, it is unlikely that most people would be able to maintain the 30-40% reduction in food intake apparently required for this intervention. Therefore, an alternative approach is needed. We first proposed the concept of caloric restriction (CR) mimetics in 1998. Since its introduction, this research area has witnessed a significant expansion of interest in academic, government, and private sectors. CR mimetics target alteration of pathways of energy metabolism to potentially mimic the beneficial health-promoting and anti-aging effects of CR without the need to reduce food intake significantly. To date, a number of candidate CR mimetics including glycolytic inhibitors, antioxidants and specific gene-modulators have been investigated and appear to validate the potential of this approach.
热量限制仍然是唯一一种在多种物种中均被持续且可重复证明能延长平均寿命和最大寿命的非基因干预措施。如果热量限制被证明适用于人类衰老，那么大多数人不太可能维持该干预措施明显所需的30%-40%的食物摄入量减少。因此，需要一种替代方法。我们于1998年首次提出了热量限制模拟物的概念。自其提出以来，这一研究领域在学术界、政府部门和私营部门的关注度显著扩大。热量限制模拟物旨在改变能量代谢途径，以潜在地模拟热量限制对健康有益和抗衰老的作用，而无需大幅减少食物摄入量。迄今为止，包括糖酵解抑制剂、抗氧化剂和特定基因调节剂在内的多种候选热量限制模拟物已得到研究，并且似乎证实了这种方法的潜力。
