Ikewuchi Catherine C, Ikewuchi Jude C, Ifeanacho Mercy O
Department of Biochemistry, Faculty of Science, University of Port Harcourt, P.M.B. 5323, Port Harcourt, Nigeria.
Department of Food, Nutrition and Home Science, Faculty of Agriculture, University of Port Harcourt, Nigeria.
BioTechnologia (Pozn). 2021 Sep 30;102(3):297-306. doi: 10.5114/bta.2021.108726. eCollection 2021.
The ability of aqueous extracts of sclerotia of and leaves of to regulate plasma markers of kidney and liver function/integrity was investigated in doxorubicin-treated Wistar rats. Doxorubicin (dissolved in normal saline) was injected intraperitoneally (15 mg/kg body weight) into the rats; metformin was daily administered orally at 250 mg/kg, while the extracts were daily administered orally at doses of 50, 75, and 100 mg/kg. Compared to the test control, in both the doxorubicin pre-treatment (or ameliorative) study and the extract pre-treatment (protective) studies, the extracts and metformin-treated groups had significantly lower ( < 0.05) plasma levels of alkaline phosphatase, alanine transaminase and aspartate transaminase, and concentrations of creatinine, urea, and blood urea nitrogen. However, the plasma globulin, albumin, and total protein concentrations and the albumin/globulin ratio of the extract and metformin-treated groups were significantly higher ( < 0.05). The extracts prevented (in the protective study) or attenuated (in the ameliorative study) doxorubicin-induced increase in the levels of plasma markers of kidney and liver function/integrity, and afforded protection or recovery towards near-normal values.
在阿霉素处理的Wistar大鼠中，研究了茯苓菌核水提取物和（原文此处缺失植物名称）叶片水提取物调节肾和肝功能/完整性血浆标志物的能力。将阿霉素（溶于生理盐水）以15mg/kg体重腹腔注射到大鼠体内；二甲双胍以250mg/kg每日口服给药，而提取物分别以50、75和100mg/kg的剂量每日口服给药。与试验对照组相比，在阿霉素预处理（或改善）研究和提取物预处理（保护）研究中，提取物组和二甲双胍处理组的碱性磷酸酶、丙氨酸转氨酶和天冬氨酸转氨酶的血浆水平以及肌酐、尿素和血尿素氮的浓度均显著降低（P<0.05）。然而，提取物组和二甲双胍处理组的血浆球蛋白、白蛋白和总蛋白浓度以及白蛋白/球蛋白比值均显著升高（P<0.05）。提取物在保护研究中预防了（或在改善研究中减轻了）阿霉素诱导的肾和肝功能/完整性血浆标志物水平的升高，并使各项指标得到保护或恢复至接近正常水平。
