Rhee Soo Hyun, Willcutt Erik G, Hartman Christie A, Pennington Bruce F, DeFries John C
Department of Psychology, University of Colorado, Boulder, CO 80309, USA.
J Abnorm Child Psychol. 2008 Jan;36(1):29-40. doi: 10.1007/s10802-007-9157-9. Epub 2007 Jul 17.
There is significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD). The conclusions of studies that examined the causes of comorbidity between ADHD and CD conflict, with some researchers finding support for the three independent disorders model and others finding support for the correlated risk factors model. We tested these models and eleven alternative hypotheses using the same analytical approach. The participants were 110 monozygotic twin pairs and 181 dizygotic twin pairs recruited from the Colorado Learning Disabilities Research Center Twin Study. The three independent disorders model did not fit the data, whereas the correlated risk factors model fit the data well. Several other comorbidity models fit the data as well as or better than the correlated risk factors model. The results suggest that correlated risk factors are a better explanation for the comorbidity between ADHD and CD than a third, independent ADHD+CD subtype.
注意缺陷多动障碍（ADHD）与品行障碍（CD）之间存在显著的共病现象。研究ADHD与CD共病原因的研究结论相互冲突，一些研究人员支持三种独立障碍模型，另一些则支持相关风险因素模型。我们使用相同的分析方法对这些模型和十一种替代假设进行了测试。参与者是从科罗拉多学习障碍研究中心双胞胎研究中招募的110对同卵双胞胎和181对异卵双胞胎。三种独立障碍模型不适合这些数据，而相关风险因素模型与数据拟合良好。其他几种共病模型与数据的拟合程度与相关风险因素模型相同或更好。结果表明，对于ADHD与CD之间的共病，相关风险因素比第三种独立的ADHD+CD亚型能提供更好的解释。
