Müzes G, Deák G, Láng I, Nékám K, Gergely P, Fehér J
2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
Acta Physiol Hung. 1991;78(1):3-9.
Superoxide dismutase activity and expression of the erythrocytes and lymphocytes of patients suffering from chronic alcoholic liver disease and those of healthy controls were investigated after in vitro incubation with silymarin. It was concluded that silymarin treatment in a concentration achievable by in vivo treatment (10 micrograms/ml) significantly increased the SOD activity of both the erythrocytes and lymphocytes of patients with liver disease, whereas the SOD expression of the lymphocytes enhanced to a considerable extent. These results indirectly indicate that the scavenger silymarin is able to increase the antioxidant protection of the cells by ameliorating the deleterious effects of free radical reactions.
在与水飞蓟素进行体外孵育后，对慢性酒精性肝病患者及健康对照者的红细胞和淋巴细胞的超氧化物歧化酶活性及表达进行了研究。得出的结论是，采用体内治疗可达到的浓度（10微克/毫升）的水飞蓟素治疗，可显著提高肝病患者红细胞和淋巴细胞的超氧化物歧化酶活性，而淋巴细胞的超氧化物歧化酶表达有相当程度的增强。这些结果间接表明，清除剂水飞蓟素能够通过改善自由基反应的有害影响来增强细胞的抗氧化保护作用。
