Láng I, Deák G, Müzes G, Prónai L, Fehér J
Second Department of Medicine, Semmelweis University, Budapest, Hungary.
Biotechnol Ther. 1993;4(3-4):263-70.
The in vitro effects of the bioflavonoid antioxidant silymarin on the expression and activity of superoxide dismutase (SOD) enzyme was studied in erythrocytes and lymphocytes from patients with chronic alcoholic liver disease. In vitro incubation with the agent in a concentration corresponding to the usual therapeutic dosage markedly increased the SOD expression of lymphocytes as measured by flow-cytofluorimetry following staining with monoclonal anti-Cu/Zn-SOD antibody and FITC-conjugated anti-mouse Ig, as well as erythrocyte and lymphocyte SOD activities. The data indirectly suggest that antioxidant activity might be one of the important factors in the hepatoprotective action of this bioflavonoid.
研究了生物类黄酮抗氧化剂水飞蓟素对慢性酒精性肝病患者红细胞和淋巴细胞中超氧化物歧化酶（SOD）表达及活性的体外影响。用对应于常用治疗剂量的浓度的该药物进行体外孵育，在用单克隆抗铜/锌超氧化物歧化酶抗体和异硫氰酸荧光素偶联的抗小鼠Ig染色后，通过流式细胞荧光测定法测量，显著增加了淋巴细胞的超氧化物歧化酶表达，以及红细胞和淋巴细胞的超氧化物歧化酶活性。数据间接表明抗氧化活性可能是这种生物类黄酮肝保护作用的重要因素之一。
