Müzes G, Deák G, Láng I, Nékám K, Gergely P, Fehér J
2nd Department of Medicine, Semmelweis University Budapest, Hungary.
Acta Physiol Hung. 1990;76(3):183-90.
Antioxidant effects of a newly developed hepatoprotective agent 4-amino-5-imidazole-carboxamide-phosphate (Aica-P) were studied in an in vitro test system using isolated peripheral blood cells from patients with chronic alcoholic liver disease and from healthy controls. In vitro incubation with the drug in a concentration corresponding to the usual therapeutic dosage enhanced the superoxide dismutase (SOD) activity of erythrocytes and lymphocytes and also increased the superoxide dismutase expression on lymphocytes. These results indirectly suggest that antioxidant capacity may be one of the important factors in the mechanisms of hepatoprotective action of the imidazole derivate Aica-P.
使用来自慢性酒精性肝病患者和健康对照者的外周血单个细胞，在体外测试系统中研究了新开发的肝保护剂4-氨基-5-咪唑甲酰胺-磷酸盐（Aica-P）的抗氧化作用。在与通常治疗剂量相当的浓度下，药物体外孵育可增强红细胞和淋巴细胞的超氧化物歧化酶（SOD）活性，并增加淋巴细胞上超氧化物歧化酶的表达。这些结果间接表明，抗氧化能力可能是咪唑衍生物Aica-P肝保护作用机制中的重要因素之一。
