Elias P M, Menon G K
Dermatology Service, Veterans Administration Medical Center, San Francisco, California 94121.
Adv Lipid Res. 1991;24:1-26. doi: 10.1016/b978-0-12-024924-4.50005-5.
As reviewed in this article, the stratum corneum must now be accorded the respect due to a structurally heterogeneous tissue possessing a selected array of enzymatic activity. The sequestration of lipids to intercellular domains and their organization into a unique multilamellar system have broad implications for permeability barrier function, water retention, desquamation, and percutaneous drug delivery. Yet, the functions and organization of specific lipid species in this membrane system are still unknown. Certain novel insights have resulted from comparative studies in avians and marine mammals. Further elucidation of the molecular architecture and interactions of lipid and nonlipid components of the stratum corneum intercellular domains will be a prerequisite for a comprehensive understanding of stratum corneum function.
如本文所述，角质层现在必须被视为一种具有特定酶活性的结构异质组织而受到应有的尊重。脂质隔离到细胞间区域并组织成独特的多层系统，这对渗透屏障功能、水分保持、脱屑和经皮给药具有广泛影响。然而，该膜系统中特定脂质种类的功能和组织仍然未知。对鸟类和海洋哺乳动物的比较研究产生了一些新见解。进一步阐明角质层细胞间区域脂质和非脂质成分的分子结构及相互作用，将是全面理解角质层功能的先决条件。
