Sung N Y, Choi K S, Park E C, Park K, Lee S Y, Lee A K, Choi I J, Jung K W, Won Y J, Shin H R
National Cancer Control Research Institute, National Cancer Center, Gyeonggi-Do, Korea.
Br J Cancer. 2007 Sep 3;97(5):700-4. doi: 10.1038/sj.bjc.6603893. Epub 2007 Jul 17.
We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 were distal gastric cancer and 1007 were unclassified. A moderate association was found between smoking, cardia and upper-third (adjusted relative risk (aRR) 2.2; 95% confidence interval (CI) 1.4-3.5) and distal cancers (aRR=1.4; 95% CI=1.3-1.6). We also found a positive association between alcohol consumption and distal (aRR=1.3; 95% CI=1.2-1.5) and total (aRR=1.2; 95% CI=1.1-1.4) gastric cancer. Combined exposure to high levels of tobacco and alcohol increased the risk estimates further; cardia and upper-third gastric cancers were more strongly related to smoking status than distal gastric cancer.British Journal of Cancer (2007) 97, 700-704. doi:10.1038/sj.bjc.6603893 www.bjcancer.com Published online 17 July 2007.
我们在一项基于人群的大型队列研究中，对669570名韩国男性参保者进行了平均6.5年的随访，调查了胃癌各亚部位发病风险与吸烟和饮酒的关系，共发现3452例新发胃癌病例，其中127例为贲门和胃上部癌症，2409例为胃远端癌症，1007例分类不明。研究发现，吸烟与贲门和胃上部癌症（校正相对风险[aRR]为2.2；95%置信区间[CI]为1.4 - 3.5）以及胃远端癌症（aRR = 1.4；95% CI = 1.3 - 1.6）之间存在中度关联。我们还发现，饮酒与胃远端癌症（aRR = 1.3；95% CI = 1.2 - 1.5）和胃癌总数（aRR = 1.2；95% CI = 1.1 - 1.4）之间存在正相关。烟草和酒精的高水平联合暴露会进一步增加风险评估；贲门和胃上部癌症与吸烟状况的关联比胃远端癌症更强。《英国癌症杂志》（2007年）97卷，700 - 704页。doi:10.1038/sj.bjc.6603893 www.bjcancer.com 2007年7月17日在线发表。
