Osterloh Anke, Breloer Minka
Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.
Med Microbiol Immunol. 2008 Mar;197(1):1-8. doi: 10.1007/s00430-007-0055-0. Epub 2007 Jul 19.
Besides their central function in protein folding and transport within the cell, heat shock proteins (HSP) have been shown to modulate innate and adaptive immune response: (1) HSP mediate uptake and MHC presentation of HSP-associated peptides by antigen-presenting cells (APC). (2) HSP function as endogenous danger signals indicating cell stress and tissue damage to the immune system. (3) HSP bind pathogen-associated molecular pattern (PAMP) molecules and modulate PAMP-induced Toll-like receptor (TLR) signaling. Thus, HSP contribute to both, recognition of "danger" defined as uncontrolled tissue destruction and recognition of dangerous "nonself". In this review these different aspects of immune stimulation by HSP will be discussed.
除了在细胞内蛋白质折叠和运输中发挥核心作用外，热休克蛋白（HSP）还被证明可调节先天性和适应性免疫反应：（1）热休克蛋白介导抗原呈递细胞（APC）对热休克蛋白相关肽的摄取和MHC呈递。（2）热休克蛋白作为内源性危险信号，向免疫系统指示细胞应激和组织损伤。（3）热休克蛋白结合病原体相关分子模式（PAMP）分子并调节PAMP诱导的Toll样受体（TLR）信号传导。因此，热休克蛋白有助于识别被定义为不受控制的组织破坏的“危险”以及识别危险的“非己”。在本综述中，将讨论热休克蛋白免疫刺激的这些不同方面。
