Almeida Cloyra, Brasil Marco Antônio, Costa Antônio José Leal, Reis Fabiola A A, Reuters Vaneska, Teixeira Patrícia, Ferreira Márcia, Marques Amanda M, Melo Bianca A, Teixeira Letícia B B de M, Buescu Alexandre, Vaisman Mário
Graduate Program in Endocrinology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Braz J Psychiatry. 2007 Jun;29(2):157-9. doi: 10.1590/s1516-44462007000200013.
To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism.
Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 microU/ml) and normal FT4, and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were evaluated. Psychiatric diagnosis was based on the Structured Clinical Interview Diagnostic for the DSM-IV axis I (SCID-I/DSM-IV), the psychopathological symptoms on Hamilton anxiety and depression scales, and the Beck Inventory.
Our data showed an increased prevalence of psychiatric disorders in the subclinical hypothyroidism patients when compared to the euthyroid group (45.7% vs 25.6%; p = 0.025), mood disorders being the most frequent. The prevalence of depressive symptoms based on Beck's Scale among subclinical hypothyroidism patients was about 2.3 times higher than among euthyroid ones (45.6% vs 20.9%, p = 0.006). Anxiety symptoms were also more frequent among subclinical hypothyroidism patients (87.0% vs 60.5%, p < 0.001), mainly clinical anxiety (44.6% vs 23.3%; p = 0.001).
Our results showed a significant association of subclinical hypothyroidism with psychiatric disorders and an increased frequency of subsyndromic depression and anxiety symptoms in subclinical hypothyroidism in relation to the euthyroid group.
评估亚临床甲状腺功能减退患者精神障碍及症状的患病率。
对来自里约热内卢联邦大学健康科学中心基金会（HUCFF-UFRJ）的94例门诊患者进行评估，这些患者血清促甲状腺激素水平至少两次升高（>4微国际单位/毫升）且游离甲状腺素（FT4）正常，另选取43例甲状腺功能正常的门诊患者作为对照。精神疾病诊断基于《精神疾病诊断与统计手册》第四版轴I障碍的结构化临床访谈诊断量表（SCID-I/DSM-IV）、汉密尔顿焦虑和抑郁量表中的精神病理症状以及贝克量表。
我们的数据显示，与甲状腺功能正常组相比，亚临床甲状腺功能减退患者精神障碍患病率更高（45.7%对25.6%；p = 0.025），情绪障碍最为常见。基于贝克量表，亚临床甲状腺功能减退患者抑郁症状的患病率比甲状腺功能正常者高约2.3倍（45.6%对20.9%，p = 0.006）。亚临床甲状腺功能减退患者的焦虑症状也更常见（87.0%对6零5%，p < 0.001），主要是临床焦虑（44.6%对23.3%；p = 0.001）。
我们的结果显示亚临床甲状腺功能减退与精神障碍之间存在显著关联，且与甲状腺功能正常组相比，亚临床甲状腺功能减退患者亚综合征性抑郁和焦虑症状的发生率增加。
