由位阻二芳基铵五氟苯磺酸盐催化的直接酯缩合反应。

Direct ester condensation catalyzed by bulky diarylammonium pentafluorobenzenesulfonates.

作者信息

Sakakura Akira, Nakagawa Shoko, Ishihara Kazuaki

机构信息

Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan.

出版信息

Nat Protoc. 2007;2(7):1746-51. doi: 10.1038/nprot.2007.254.

DOI:10.1038/nprot.2007.254

PMID:17641640

Abstract

A protocol for ester condensation between equimolar amounts of carboxylic acids and alcohols catalyzed by bulky diarylammonium pentafluorobenzenesulfonate is described. We also present procedures for the synthesis of N-(2,6-diisopropylphenyl)-N-mesitylammonium pentafluorobenzenesulfonate. The present ester condensation proceeds well under mild conditions even without the removal of generated water. The synthesis of N-(2,6-diisopropylphenyl)-N-mesitylammonium pentafluorobenzenesulfonate will take approximately 5 days. The ester condensation reactions will take approximately 6 h to 3 days.

摘要

描述了一种由大位阻二芳基铵五氟苯磺酸盐催化等摩尔量羧酸和醇之间进行酯缩合的方案。我们还给出了N-(2,6-二异丙基苯基)-N-均三甲苯基铵五氟苯磺酸盐的合成步骤。即使不除去生成的水，当前的酯缩合反应在温和条件下也能顺利进行。N-(2,6-二异丙基苯基)-N-均三甲苯基铵五氟苯磺酸盐的合成大约需要5天。酯缩合反应大约需要6小时至3天。