Chen Hai-Ying, Guo Jia-Long, Li Zhan-Guo
Department of Rheumatology & Immunology, Beijing University, People's Hospital, Beijing, China.
Clin Rheumatol. 2008 Feb;27(2):183-7. doi: 10.1007/s10067-007-0675-1. Epub 2007 Jul 21.
The aim of this study was to evaluate the value of anti-cell membrane-associated DNA (mDNA) antibodies in the diagnosis of systemic lupus erythematosus (SLE). Antibodies against mDNA were detected with indirect immunofluorescence assay in 207 SLE, 167 other rheumatic diseases, and 82 healthy controls. Association of clinical features and anti-mDNA antibodies was analyzed. The prevalence of anti-mDNA antibodies was 73.3% in SLE, 8.3% in Sjögren's syndrome, and 4.8% in rheumatoid arthritis. The incidences of anti-mDNA antibodies in SLE lacking antideoxyribonucleoprotein, antihistone antibodies, antinuclesome antibodies, anti-dsDNA, and anti-Sm antibodies were 73.8, 62.7, 65.3, 57.8 and 51.6%, respectively. Skin rash, alopecia, oral ulcer, and joint pain are more common in patients with anti-mDNA antibodies. The anti-mDNA antibody is one of the most valuable markers in SLE. It is also informative in some SLE patients lacking other autoantibodies.
本研究旨在评估抗细胞膜相关DNA（mDNA）抗体在系统性红斑狼疮（SLE）诊断中的价值。采用间接免疫荧光法检测了207例SLE患者、167例其他风湿性疾病患者及82例健康对照者血清中的抗mDNA抗体，并分析了其临床特征与抗mDNA抗体的相关性。SLE患者抗mDNA抗体阳性率为73.3%，干燥综合征患者为8.3%，类风湿关节炎患者为4.8%。在缺乏抗脱氧核糖核蛋白、抗组蛋白抗体、抗核小体抗体、抗双链DNA及抗Sm抗体的SLE患者中，抗mDNA抗体的阳性率分别为73.8%、62.7%、65.3%、57.8%及51.6%。抗mDNA抗体阳性的患者皮疹、脱发、口腔溃疡及关节疼痛更为常见。抗mDNA抗体是SLE最有价值的标志物之一，在某些缺乏其他自身抗体的SLE患者中也具有重要意义。
